Diane M Simeone Selected Research

3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamide

6/2012	Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.
6/2011	Assessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.
6/2010	Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

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Diane M Simeone Research Topics

Disease

77	Neoplasms (Cancer) 01/2022 - 05/2003
72	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021 - 08/2004
25	Adenocarcinoma 01/2022 - 08/2004
16	Chronic Pancreatitis 01/2016 - 08/2004
10	Neoplasm Metastasis (Metastasis) 01/2021 - 03/2007
6	Cysts 11/2021 - 01/2011
5	Pancreatic Cyst 11/2021 - 05/2012
5	Circulating Neoplastic Cells 12/2019 - 12/2014
5	Pancreatitis 01/2018 - 06/2008
5	Carcinogenesis 01/2016 - 03/2008
3	Neuroendocrine Tumors (Neuroendocrine Tumor) 12/2014 - 02/2007
2	Pain (Aches) 01/2020 - 01/2016
2	Hepatocellular Carcinoma (Hepatoma) 12/2019 - 12/2014
2	Urinary Bladder Neoplasms (Bladder Cancer) 01/2018 - 12/2015
2	Hypoxia (Hypoxemia) 01/2018 - 08/2004
2	Breast Neoplasms (Breast Cancer) 03/2013 - 10/2012
2	Neoplasms, Cystic, Mucinous, and Serous 01/2011 - 05/2010
2	Disease Progression 01/2009 - 12/2008
1	Aneuploidy (Aneuploid) 01/2021
1	Fatigue 01/2020
1	Genomic Instability 07/2019
1	Ovarian Neoplasms (Ovarian Cancer) 10/2018
1	Triple Negative Breast Neoplasms 10/2018

Drug/Important Bio-Agent (IBA)

27	Biomarkers (Surrogate Marker)IBA 01/2020 - 09/2006
27	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2004
15	Gemcitabine FDA Link 01/2019 - 10/2007
11	Glycoproteins (Glycoprotein)IBA 01/2015 - 07/2006
7	Biological ProductsIBA 01/2021 - 05/2007
6	Polysaccharides (Glycans)IBA 01/2016 - 07/2006
6	LectinsIBA 08/2011 - 07/2006
5	Epithelial Cell Adhesion MoleculeIBA 01/2017 - 02/2007
4	RNA (Ribonucleic Acid)IBA 12/2020 - 03/2013
4	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2019 - 10/2007
4	AutoantibodiesIBA 06/2009 - 08/2004
3	ProteomeIBA 01/2021 - 07/2010
3	EnzymesIBA 01/2021 - 10/2012
3	Pharmaceutical PreparationsIBA 01/2021 - 12/2014
3	DNA (Deoxyribonucleic Acid)IBA 07/2019 - 03/2014
3	CytokinesIBA 01/2016 - 09/2012
3	HaptoglobinsIBA 04/2014 - 05/2007
3	Wheat Germ AgglutininsIBA 10/2013 - 07/2006
3	AntibodiesIBA 10/2013 - 08/2004
3	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamideIBA 06/2012 - 06/2010
3	Neoplasm Antigens (Tumor Antigens)IBA 06/2009 - 08/2004
2	Carcinoembryonic AntigenIBA 11/2021 - 05/2010
2	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 08/2004
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 07/2015
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2020 - 01/2016
2	130-nm albumin-bound paclitaxelIBA 01/2019 - 01/2016
2	Fluorouracil (Carac)FDA LinkGeneric 01/2019 - 01/2016
2	Leucovorin (Folinic Acid)FDA Link 01/2019 - 01/2016
2	trametinibIBA 12/2018 - 10/2018
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2018 - 10/2018
2	LigandsIBA 10/2018 - 08/2013
2	Phosphotransferases (Kinase)IBA 10/2018 - 03/2013
2	LuciferasesIBA 01/2018 - 06/2010
2	graphene oxideIBA 06/2016 - 10/2013
2	OligosaccharidesIBA 01/2016 - 03/2007
2	MicroRNAs (MicroRNA)IBA 12/2015 - 03/2012
2	UbiquitinIBA 11/2015 - 09/2012
2	GlycopeptidesIBA 04/2015 - 07/2006
2	Peptides (Polypeptides)IBA 04/2015 - 12/2014
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 12/2014 - 12/2013
2	Small Interfering RNA (siRNA)IBA 01/2014 - 03/2007
2	Blood Proteins (Serum Proteins)IBA 08/2011 - 01/2009
2	CarbohydratesIBA 01/2011 - 07/2006
2	AgglutininsIBA 05/2010 - 07/2006
2	Collodion (Nitrocellulose)IBA 01/2010 - 06/2009
2	Complement C1 Inhibitor Protein (C1 Esterase Inhibitor)IBA 05/2007 - 07/2006
2	Protein Isoforms (Isoforms)IBA 01/2006 - 08/2004
1	butyrylcarnitineIBA 11/2021
1	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 11/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	TESIBA 01/2020
1	Circulating Tumor DNAIBA 01/2019
1	Genetic Markers (Genetic Marker)IBA 01/2019
1	Bevacizumab (Avastin)FDA Link 01/2019
1	Adenosine Monophosphate (AMP)IBA 01/2019
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2018
1	palbociclibIBA 12/2018
1	tyrosine receptor (receptor, tyrosine)IBA 10/2018
1	Drug CombinationsIBA 10/2018
1	SHP099IBA 10/2018
1	CeruletideIBA 01/2018
1	Arginine (L-Arginine)FDA Link 01/2018
1	Deubiquitinating EnzymesIBA 01/2018
1	Oxygen (Dioxygen)IBA 01/2018
1	Fibrinogen (Factor I)FDA Link 01/2018
1	Doxycycline (Periostat)FDA LinkGeneric 01/2018
1	cabozantinibIBA 12/2016
1	PolymersIBA 06/2016

Therapy/Procedure

28	Therapeutics 01/2021 - 08/2004
16	Drug Therapy (Chemotherapy) 01/2022 - 06/2006
8	Radiotherapy 10/2017 - 06/2006
3	Precision Medicine 01/2021 - 01/2015
3	Lab-On-A-Chip Devices 12/2019 - 12/2014
2	Immunotherapy 01/2021 - 06/2006
2	Chemoradiotherapy 10/2017 - 01/2016